Poison is a serial killer and poisoner. Along with The Cannibal, Ugly Face and The Strangler, she escaped custody when the police bus crashed. She tried to murder Mr. BoJenkins by seducing him. He invited her into his cabin and while he looked away to undress, she tried to slip poison into his martini. Mr. Pickles saved him by twisting Poison's neck in time, causing her head to rotate 180 degrees.
Poison resembles an attractive, older African American woman with frizzy hair and dark eyes. She's recognized by a pair of skull earrings.